Taken together, five genes identified as responsive to XBP-1s in the transcriptomic data with a previously known association with ATF6n (csp-1, dnj-28, hsp-4, ckb-2, and lipl-3; Table 2) are all essential for xbp-1s-mediated tauopathy suppression in C. elegans. The gene discussed is CSP1; the disease is tauopathy.