However, eol-1 loss of function blocked the ability of xbp-1s Tg to suppress tau-induced behavioral defects in Tau (high); xbp-1s Tg; eol-1 (−/−) animals when compared to Tau (high); xbp-1s Tg animals (Fig. 6e), which indicates eol-1 is also required for xbp-1s- mediated suppression of tauopathy. The gene discussed is MAPT; the disease is tauopathy.