Interestingly, csp-1 (−/−) loss of function abolished the ability of xbp-1s to suppress locomotion defects as seen in Tau (high); xbp-1s Tg; csp-1 (−/−) animals compared to Tau (high); xbp-1s Tg animals (Fig. 2a), which suggests csp-1 upregulation by xbp-1s is necessary for xbp-1s-mediated tauopathy suppression. This evidence concerns the gene MAPT and tauopathy.