In addition to the five genes identified with a previously known association with ATF6 (csp-1, dnj-28, hsp-4, ckb-2, and lipl-3; Table 2), each of the six XBP-1s target genes without previous association with ATF6 (erp-44.3, F41E7.6, C01B4.6, Y19D10A.16, eol-1, and mct-2; Table 1) must be intact for XBP-1s-mediated suppression of tauopathy in C. elegans. The gene discussed is CSP1; the disease is tauopathy.