To investigate whether eol-1 is required for xbp-1s-mediated tauopathy suppression in C. elegans, we used an eol-1 loss-of-function mutant strain [eol-1 (gk534833); referred to as eol-1 (−/−)] crossed to Tau (high); xbp-1s Tg animals. Here, MAPT is linked to tauopathy.