The molecular chaperone binding immunoglobulin protein (BiP), phosphorylated PERK (pPERK), eukaryotic initiation factor 2 α (eIF2α), and IRE1α are upregulated in hippocampal neurons in AD25,26, while pPERK and phosphorylated IRE1α are increased in PSP, PiD, and FTLD-tau27,28. Here, HSPA5 is linked to supranuclear palsy, progressive, 1.