MAPT and tauopathy: When compared to Tau (high); xbp-1s Tg animals, Tau (high); xbp-1s Tg; hsp-3 (−/−) animals exhibited similar suppression of tauopathy-induced locomotion defects (Fig. 4d), indicating hsp-3 loss of function is dispensable for xbp-1s-mediated tauopathy suppression.