To understand whether functional LIPL-3 is necessary for xbp-1s-mediated tauopathy suppression, we crossed Tau (high); xbp-1s Tg animals with a loss-of-function mutant strain [lipl-3 (gk846191); referred to as lipl-3 (−/−)] and explored the effect on tauopathy locomotion defects. This evidence concerns the gene LIPM and tauopathy.