Flow cytometry confirmed substantially lower numbers of CD4+ T cells, CD8+ T cells, Th1 helper cells, and IL-17-secreting (Th17) helper cells, important disease drivers in MS and EAE21,22, in EAE brains and spinal cords at D16 after A13 administration (Fig. 1e and Supplementary Fig. 1a, b). This evidence concerns the gene CD4 and myeloid sarcoma.