AQP3 and neoplasm: After inhibiting AQP3 expression in M2 macrophages and co-cultivating with cancer cells, we found that M2 macrophages with AQP3 knockdown could significantly reduce the proliferation, cell cycle, and migration of tumor cells compared with the control group by CCK-8, EdU, flow cytometry, and transwell assay (Fig. 5 and S4).