FoxO1 also binds to the Cat and Mnsod promoters where C/EBP-β binds but FoxO1 binding to the Cat and Mnsod promoters was reduced in the presence of ischemia or in C/EBP-β-KI, suggesting that FoxO1 and C/EBP-β bind to the same sites on the Cat and Mnsod promoters and that their binding may be competitive (Fig. 7d). The gene discussed is SOD2; the disease is ischemia.