MST1 and myocardial ischemia: To validate the salutary effect of Mst1-induced phosphorylation of C/EBP-β during myocardial ischemia, C/EBP-β-T250E knock-in (C/EBP-β-KI) mice were generated, using the CRISPR/Cas9 system (Supplementary Fig. 12).