FOXO1 and ischemia: Furthermore, cardiac-specific C/EBP-β knockout (C/EBP-β cKO) mouse hearts exhibited greater MI than WT hearts following 4 h of ischemia, which was not rescued by FoxO1 overexpression, consistent with the notion that the protective effect of FoxO1 during ischemia is mediated through endogenous C/EBP-β (Supplementary Fig. 11).