BNIP3 and ischemia: ChIP sequencing analyses also showed that FoxO1 binding to the promoter of pro-apoptotic genes, including Bcl2l11, Fadd, Bnip3, and Pmaip1, was decreased in the presence of ischemia or in C/EBP-β-KI, without concomitant increases in C/EBP-β binding to the promoter (Supplementary Fig. 15).