Altogether, this could improve fitness and persistence of UCARTCS1 cells.7 38 39 We also show that SLAMF7 gene-editing did not affect the cytotoxic capacity of SLAMF7-targeting CAR T-cells, which is in agreement with a previous study showing that SLAMF7 was not required for CAR T-cell efficacy in an MM mouse model.21 The gene discussed is SLAMF7; the disease is Miyoshi myopathy.