Here, we investigate the regulation of WWP1, a versatile E3 that ubiquitinates and regulates the stability, activity, or cellular localization of several proteins crucial for cancer progression such as transforming growth factor-beta (TGF-ß) type I receptor (6, 7), PTEN (8, 9, 10), LATS1 (11), KLF5 (12), or the members of the p53 superfamily proteins DNp63a, TAp63a, and DNp73 (13). This evidence concerns the gene WWP1 and cancer.