This changes how albumin is distributed between the inside and outside of blood vessels.[34,35] A negative correlation between CRP and albumin levels in COVID-19 patients, a sign of inflammatory status, has been demonstrated.[17,34,35] Similar to the relationship between CRP and albumin levels, a significantly negative correlation was found between neopterin and albumin levels in patients with severe COVID-19 in our study. The gene discussed is ALB; the disease is COVID-19.