TGIF1 (OMIM:602630) encodes transforming growth factor-β-induced factor, which belongs to a family of evolutionarily conserved, atypical homeodomain proteins that act as transcriptional repressors and co-repressors in retinoid and transforming growth factor signaling pathway.[19]TGIF1 has been proposed as a candidate gene which is implicated in the etiology of HPE in patients with chromosome 18p deletions. The gene discussed is TGIF1; the disease is holoprosencephaly.