In addition, after combing and analyzing the role of tau in AD, Rik et al concluded that the expression of plasma p-tau combined with brief cognitive tests and apolipoprotein genotyping could more accurately predict the early individual development of AD, and also emphasized the key role of blood p-tau in the pathogenesis of AD.[57] All of this suggests that tau in the blood, p-tau is a key biomarker for early identification of AD. This evidence concerns the gene MAPT and Alzheimer disease.