A recent respiratory tract infection history may be another risk factor for spontaneous dissections.[7] Genetic alterations have been confirmed to be associated with CAD,[8] such as hyperhomocysteinemia, variation in PHACTR1 and so on.[9,10] CAD is also a frequent manifestation of fibromuscular dysplasia.[11] In young patients, migraine, especially migraine without aura, is consistently associated with CAD.[12]. The gene discussed is PHACTR1; the disease is Respiratory tract infection.