Moreover, we found statistically significant correlations between increases in brain glutathione and reductions in plasma TNF-α (indicating decreased inflammation; r = −0.53; P = .05) in patients with MCI or mild dementia (MMSE ≥ 20) and reductions in ADAS-Cog11 scores (indicating improved cognition; r = −0.45; P = .034) in all 23 patients. The gene discussed is TNF; the disease is dementia.