Consistent with previous findings that Yptb-induced cell death does not require caspase-1 or caspase-11 (24, 25), caspase-1 DEAD cells exhibited WT levels of lactate dehydrogenase (LDH) release upon infection with Yptb (Fig. 2C) but failed to induce LDH release upon infection with S. Typhimurium, (Fig. 2C and fig. The gene discussed is CASP1; the disease is infection.