CASP1 and infection: Consistently, while Casp1−/− immortalized BMDMs (iBMDMs) stably expressing WT caspase-1 robustly processed caspase-1 upon infection with Salmonella Typhimurium or Yptb (Fig. 2B), iBMDMs expressing catalytically inactive caspase-1, known as caspase-1 DEAD (C284A) (33) were unable to process caspase-1 during either Salmonella or Yptb infection.