Moreover, the RIPK3 inhibitor GSK′872 inhibited both cell lysis and caspase-1 processing in Casp8D387A/D387A but not WT BMDMs following Yptb infection or LPS/IKKi treatment, suggesting that caspase-8 auto-processing during Yersinia infection or IKK/TAK1 blockade normally limits RIPK3-mediated necroptosis and subsequent caspase-1 activation (Fig. 3, A to C). Here, CASP1 is linked to Yersinia infectious disease.