The expression increase of TRAF6 and NFκB1 in RA patients synovium promotes a higher concentration of inflammatory cells in the joint and, consequently, tissue damage in the synovium (Zhu et al., 2012; Świerkot et al., 2016; Liu et al., 2017; Puchner et al., 2018). The gene discussed is TRAF6; the disease is rheumatoid arthritis.