ODC1/SRM knockdown, which decreased polyamine levels in the tumor tissue (Figure 2N), did not affect primary tumor growth rate or paclitaxel sensitivity (Figure 2L), but attenuated paclitaxel‐induced enrichment of ALDH+ cells (Figure 2M), indicating that genetic inhibition of polyamine anabolism successfully blocks chemotherapy‐induced BCSC enrichment. This evidence concerns the gene LDHA and neoplasm.