Currently, in addition to thick smears, the Brazilian National Malaria Prevention and Control Program (PNCM) has used SD-BIOLINE MALARIA AG Pf/Pf/Pv® to diagnose malaria, a combined test that detects the HRP2 and pLDH antigens of P. falciparum and pLDH from P. vivax. It has proven to be quite efficient in supporting malaria diagnosis in the country [22,23]. The gene discussed is HDGFL2; the disease is malaria.