CD8A and infection: The paucity of CD8+ T cells in the lymphoid follicle likely provides a morefavorable environment for HIV-1 reservoir maintenance in the germinal centerthan the extrafollicular region (53).However, given the relative immune-sequestered nature of the follicle, itneeds to be explored whether HIV-infected cells can shift from theextrafollicular zone during early infection to the B cell zone of the lymphnode during chronic infection.