Deletion of MKC1, encoding a kinase in the cell wall integrity pathway, affected hyphal growth in vitro, but not in a mouse ear tissue infection model that allows intravital imaging; the authors previously showed discrepencies between in vitro and in vivo hyphal phenotypes of mutants of TPK1 and TPK2, which encode protein kinase A, using the same model (8). The gene discussed is TPK1; the disease is infection.