Comparative studies in murine experimental models have described how infection with L. guyanensis parasites carrying LRV1 (LgyLRV1+), unlike LgyLRV1−, leads to low NO production that allows parasite dissemination and metastasis (developing severe lesions), mediated by elevated IL-17 synthesis in lymph nodes draining the initial site of infection [158]. Here, IL17A is linked to infection.