TLR2-mediated recognition of the LPG on the surface of L. major, L. mexicana, and L. aethiopica triggers the development of a protective immune response by increasing ROS and NO production, while in L. amazonensis and L. braziliensis, recognition of the LPG (of a different thickness than the other species) activates TLR2 to promote the persistence of infection [152]. Here, TLR2 is linked to infection.