MAPT and neuroblastoma: Prior studies that analyzed the interaction of cytotoxin VII4 with mitochondria in mouse primary cortical neurons, human SH-SY5Y neuroblastoma cells, and model cardiolipin-containing membranes [36] suggested that cytotoxin exhibited neurotoxicity via triggering pathological reactions in the mitochondria of nerve cells in a similar manner to amyloidogenic proteins such as alpha-S, betta-amyloid, tau, through targeting cardiolipin.