Moreover, serum containing overexpressed ANXA2 showed higher levels of IL-6; the siRNA-mediated inhibition of ANXA2 expression in prostate cancer cells reduced IL-6 secretion, while the restoration of ANXA2 expression by transfection of the ANXA2 gene normalized IL-6 secretion [49]. The gene discussed is ANXA2; the disease is prostate carcinoma.