While the Bregs are known to be involved in several pathologies, such as cancer, multiple sclerosis, and systemic lupus erythromatosis [93], evidence shows variation in the elevated frequencies of two Bregs subpopulations, namely, CD24+/highCD27+ and CD24highCD38high, and enhanced IL-10 expression levels in hepatitis B non-responders [94,95]. This evidence concerns the gene IL10 and hepatitis B virus infection.