In CNS, both RIPK1 and RIPK3 are implicated in playing a role in neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis (ALS), AD, and PD by promoting neuroinflammation, cytokine production by microglia, and astrocyte and neuronal cell death [33,34,35,36]. The gene discussed is RIPK1; the disease is amyotrophic lateral sclerosis.