IRF7 and infection: Figure 1B presents the number of DEGs at days 1, 3, and 6 post-SARS-CoV-2 infection. In total, 104 genes were significantly upregulated, and 89 genes were significantly downregulated at 6 days post-infection (D6), whereas there were no upregulated genes and only six downregulated genes at 1 day post-infection (D1). To show gene dysregulation, we generated a Venn diagram, and it showed 16 genes, including Cxcl10 (encoding IP-10), Ccl2 (encoding MCP-1), Zbp1, and Irf7, commonly dysregulated in response to SARS-CoV-2 infection (Figure 1C).