In the oncologic field, these parameters may play a pivotal role in tumor management, including diagnosis, characterization, grading, assessment of tumor invasiveness, staging, histopathological and molecular typing (ki-67 or PD-L1 expression, HER-2 status, K-RAS mutations, etc.), prognostic and predictive value, treatment planning, response assessment, and follow up [80,81,82,83,84,85,86,87,88,89,90,91]. Here, MKI67 is linked to neoplasm.