While no effect of insulin resistance or BCAA treatment was observed for Mitofusin 1 (Mfn1), Mitofusin 2 (Mfn2), or Dynamin-1-like protein (Dnm1l) also referred to as Dynamin-related protein 1 (Drp1) (Figure 4a, b, and d, respectively), a main effect for insulin resistance and significant interaction effect was observed for (Fis1), which was downregulated in insulin-resistant cells (Figure 4c). The gene discussed is FIS1; the disease is Insulin resistance.