The ORs with 95% CI for the association between insulin sensitivity and metabolic abnormalities from the lowest to highest tertile of KITT (SLD, metabolic syndrome, albuminuria and diabetic retinopathy) include 2.499 (1.968–3.714), 2.971 (2.520–3.503), 3.098 (2.605–3.684) and 2.066 (1.514–2.819), respectively (p for trend < 0.001). The gene discussed is INS; the disease is metabolic syndrome.