On the other hand, in a nested case/control study performed by Wang et al. in women during early pregnancy, methylation levels at six CpGs sites within the RHO Guanosine triphosphatase activating protein 40 (ARHGAP40), signal transducer and activator of transcription 1 (STAT1), C5orf34, retinol dehydrogenase 12 (RDH12), and YAP1 genes were significantly higher in the GDM group than in controls, and another six CpGs sites within the HAPLN3, the interferon gamma receptor 2 (IFNGR2), YAP1, nuclear factor of activated T cells 4 (NFATC4), and DNAJB6 genes were significantly lower. The gene discussed is HAPLN3; the disease is gestational diabetes.