NOTCH1 and congenital bilateral aplasia of vas deferens from CFTR mutation: Any minor change in the molecular signals regulating cell differentiation, proliferation, apoptosis and migration of aortic valve cells, as well as the organization of the extracellular matrix due to tiny modulation of Notch1-Wnt-signaling, can cause congenital heart valve defects, including BAV, that will directly affect the predisposition to CAVD [9].