An association analysis revealed a common variant rs3812603 in the intron of NOTCH1 (NC_000016.10:g.136508456T>C, rs3812603) underrepresented in the study group (atrial fibrillation (AF) in CAVD group 0.42, AF in controls 0.59, p-value = 1.90 × 10−5; β = −0.0112) and a common variant in intron of DVL3 (NC_000003.12:g.184168569C>T, rs73185723) overrepresented in CAVD patients (AF in CAVD group 0.22, AF in controls 0.12, p-value = 1.49 × 10−4; β = 0.0149). Here, DVL3 is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.