NPPB and atrial fibrillation: Another analysis of RELAX study revealed that higher NT-proBNP/cGMP ratio was associated with greater left ventricular mass and troponin levels, higher prevalence of atrial fibrillation, lower estimated glomerular filtration rate and peak oxygen consumption, but even this adverse cardiometabolic profile was not improved by the administration of selective phosphodiesterase-5 inhibition [59].