CDKN2B and coronary artery disorder: For instance, the 9p21 locus [CDKN2B-AS1] has also been associated with a number of cardiovascular manifestations including MI [10], coronary artery disease (CAD) [5,11], risk of abdominal and intracranial aneurysms [12], peripheral arterial disease [12], heart failure [13], sudden cardiac death [14], and stroke [15].