HIF1A and cocaine dependence: A further Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of overlapping targets revealed that Pol was mainly involved in cancer pathways, Alzheimer’s disease, cocaine addiction, and the HIF-1 signaling pathway (Figure 8D), and Asp G was mainly involved in cocaine addiction, amphetamine addiction, insulin resistance, and the adipocytokine signaling pathway (Figure 8E).