LCE treatment reversed the expression of E- and N-cadherin induced by TGF-βin PC3 and Du145 cells, as demonstrated by fluorescent and Western blotting assays, indicating that LCE treatment inhibited the migration and invasion of cancer cells while increasing the expression of E-cadherin and decreasing the expression of N-cadherin (Figure 6D,E). Here, CDH2 is linked to cancer.