The results of this study suggest that the mitochondrial-dependent apoptotic pathway is also involved in the anti-tumor process of brown seaweed polysaccharides, as there was a significant decrease in the expression level of the anti-apoptotic factor Bcl-2 and a significant increase in the expression level of the pro-apoptotic factor, the Bax gene, in tumor cells. The gene discussed is BCL2; the disease is neoplasm.