Han and colleagues contributed findings with the terpenoid astaxanthin (84), present in the red-orange pigment Asteroidea, salmon, trout, and the shells of crustaceans, that protected against memory impairment in a murine model of AD via binding to signal transducer and activator of transcription 3 (STAT3) and inhibiting phosphorylation and activation, resulting in reduced Ab levels and b-secretase (BACE1) activity [115]. This evidence concerns the gene STAT3 and Alzheimer disease.