CD86 and Hyperkeratosis: Moreover, POE was able to inhibit the hallmark histological aspects of psoriasiform dermatitis, such as thickness of stratified squamous epithelium, hyperkeratosis, parakeratosis, agranulosis, dilatation, and congestion of the dermal capillaries and development of Munro’s micro abscesses [32], and to reduce infiltration of inflammatory macrophages and T lymphocytes, as revealed by reduction in expression of CD86 and CD3 markers.