The NF-κB pathway is involved in cancer metastasis via regulation of metalloproteinases MMP-2/9, which plays a key role in HCC invasion and metastasis, and consequently reduces MMP-2/9 in HepG2 cells under high glucose (HG) conditions; these cells are used as an in vitro model of HCC [105]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.