The present study confirmed several risk factors that should trigger the investigations for an IFD: AML diagnosis, ICU setting for more than a week, administration of more than seven antimicrobials during the last trimester, history of severe neutropenia for 1.5 months, fungal colonization in sites other than the oral cavity, fever > 38.8 °C for >12 days, CRP levels above 10 mg/dL, treatment with prednisolone equivalent ≥ 0.3 mg/kg for more than three weeks, and IVIG administration. This evidence concerns the gene CRP and acute myeloid leukemia.