Temperature dependence of hTTR formation highlights therole water molecules play in the stabilization of TTR tetramer structureand provides a rationale for TTR disassembly and progression of SUE.The observation that disruption of water molecule structure can promotehTTR formation may indicate that environmental factors known to affecthydration (i.e., temperature, osmolytes, pH, chemical denaturants)could play a role in progression of TTR diseases including amyloidosis. This evidence concerns the gene TTR and amyloidosis.