In a correlation analysis between the BRAF mutation, Ki-67 expression, their combination and various clinical and pathological parameters in PTC patients, older age was positively correlated with a higher frequency of the BRAF V600E mutation (r = 0.284; p < 0.001), while a more advanced tumor stage was positively correlated with a higher Ki-67 LI (r = 0.307; p < 0.001) [20]. This evidence concerns the gene BRAF and neoplasm.