Despite the fact that DC:T cell crosstalk and the NLRP3-dependent activation of circulating leukocytes are crucially responsible for the development of systemic immune response in patients suffering from COPD, ulcerative colitis (UC), and diabetes mellitus (DM), the long-term effects of HTPs on immune-cell-driven systemic inflammation are still unknown [16]. This evidence concerns the gene NLRP3 and diabetes mellitus.