In our results, EvC ciliary subunit 2, joining chain of multimeric IgA and IgM, protocadherin 17, and albumin proteins were identified in greater abundance in the neoplasia groups of samples enriched with serum EVs; however, it is possible to observe that in most studies, these proteins and their coding genes are generally found in lower abundance and expression when studied in neoplastic tissues, free in blood serum, and in tumor-derived EVs [83,93,98,102]. This evidence concerns the gene PCDH17 and neoplasm.