In prostate cancer in men, the exacerbated methylation of the gene encoding this protein, obtained by PCR in tissue, was related to a higher pathological grade, lymph nodes with metastases, and a lower survival rate, with PCDH17 hypermethylation being suggested as a possible biomarker of this neoplasm [99]. The gene discussed is PCDH17; the disease is Familial prostate cancer.