ESR1 and cancer: The inhibition of cancer cells by WA may be the result of the following molecular mechanisms: induction of apoptosis; induction of oxidative stress; reduction of NF-κB, STAT3, and estrogen receptor expression; inhibition of the cell cycle in the G2-M phase, proteasomes, and processes important for the spread of cancer cell metastases [16,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51].