MPO and eosinophilic granulomatosis with polyangiitis: Hence, the genetic association resembled the specific ANCA features, proposing a more autoimmune profile in MPO-ANCA-positive EGPA, almost completely driven by the HLA complex, compared to a more eosinophilic and mucosal signature in ANCA-negative EGPA, characterized by the impact of non-MHC genes.