The rationale for implicating the Gas6/TAM axis in SSc derives from the proven involvement of the system in vascular integrity and its overexpression in vascular injury, the role of Gas6/TAMs in efferocytosis, which is a fundamental mechanism for the prevention of autoimmunity, and the interplay of Gas6/TAMs in inflammation and fibrosis. Here, GAS6 is linked to systemic sclerosis.