The ability of UV to induce miRNA-21 overexpression in melanoma involves the ROS-mediated modulation of transcription factors such as the signal transducer and activator of transcription 3 (STAT3), activator protein 1 (AP-1), and NF-κB, which all have recognition sites on the miRNA-21 promoter [91]. This evidence concerns the gene STAT3 and melanoma.