The diffuse astrocytoma, IDH-wild-type, WHO grade II, as well as the anaplastic astrocytoma IDH-wild-type WHO grade III, will both become glioblastoma IDH-wild-type CNS WHO grade 4 if they feature TERT promoter mutation, EGFR amplification, and/or +7/−10) [10]. This evidence concerns the gene IDH2 and diffuse astrocytoma.