Consistent with prior discussions, it has been stated that EGFR amplification along with mutation of TERT promoter and 7+/10− are alterations very often present in adult patients with IDH-wild-type GBM, and they can contribute to the upgrade of diffuse or anaplastic astrocytoma to wild-type GBM [88]. The gene discussed is IDH2; the disease is anaplastic astrocytoma.