IGHE and Allergy: Additionally, it was demonstrated that TSLP-activated DCs encourage naive CD4+ T cells to develop into T follicular helper cells (expressed by CXCR5, IL-21, CXCL13, and BCL6), which can then trigger memory B cells to secrete IgG and IgE, establishing a connection between TSLP and IgE production in allergy development.