We have also demonstrated the promising potential of several DNA methylation markers, including A Disintegrin-like Metalloproteinase with Thrombospondin type 1 motif 1 (ADAMTS1), Basonuclein 1 (BNC1), leucine-rich repeat and fibronectin type III domain containing 5 (LRFN5), and Peroxidasin (PXDN) in pancreatic cancer for early detection, and ADAMTS1, BNC1, and calcium voltage-gated channel subunit alpha1 G (CACNA1G) in malignant risk stratification of intraductal papillary mucinous neoplasms (IPMNs) at our laboratory [104,180,181,205]. This evidence concerns the gene LRFN5 and familial pancreatic carcinoma.