The anti-tuberculosis effect could be by two ways: (1) inhibiting the enzymatic action of PanK blocking the synthesis of coenzyme A (CoA), which plays a crucial role as a carrier of acyl groups and is vital for the processes of respiration and lipid metabolism in Mtb; and (2) inhibiting the catalytic function of UGM by blocking the interconversion between UDP-galactopyranose (UDP-GalP) and UDP-galactofuranose (UDP-GalF), a critical step in the formation of the Mtb cell wall. The gene discussed is PANK1; the disease is tuberculosis.