The phenotype appears to be influenced by the location of APC mutations, leading to two distinct clinical scenarios: classical familial adenomatous polyposis (including profuse familial adenomatous polyposis with over 1000 adenomas along the colonic mucosa and sparse familial adenomatous polyposis with 100–1000 polyps) and attenuated familial adenomatous polyposis with 10–99 adenomas, predominating in the right colon [132]. Here, APC is linked to adenoma.