Figure 3C shows the KEGG enrichment analysis results for the 56 genes with thyroid hormone signalling pathways and pathways in cancer. The labelled genes also contained an ESR signal. After merging 87 and 56 genes and removing duplicate genes, the protein–protein interaction (PPI) network analysis results for 126 genes were obtained, as shown in Figure 3D. The pink arrow indicates that the ESR gene is arranged in fifth place. Therefore, we conducted homology modelling and E2 docking on the SNP of the ESR gene. Here, ESR1 is linked to cancer.